Gennaro, the son of Lucretia Borgia, lives unaware of the identity of his mother, who has married the Duke of Ferrara. After Lucretia's brother is killed by five conspirators, the fathers of Gennaro's dearest friends, Lucretia tortures the old men to death. Later, Gennaro and his companions journey to Lucretia's domain, and she sees her son for the first time. The Duke, who believes him to be her lover, poisons him, but Lucretia administers the antidote in time and saves his life. Then she schemes to poison her sons' five friends for their fathers' mistake.

Florence Reed
Lucretia Borgia
William E. Shay
The Duke of Ferrara

Stephen Grattan
Lucretia's Brother

Richard Barthelmess
Gennaro
Alex Shannon
Rustighello
A.G. Parker
Maffio
M.J. Briggs
Astolpo
Edward Thorne
Jeppo
Elmer Patterson
Liverretto
Tony Merlo
Petrucci

Henry Armetta
The Jester

William Welsh
Gubetta

Doctor Who: Marco Polo
Doctor Who: Marco Polo

Subway Sadie
Subway Sadie

The Lily
The Lily

One Increasing Purpose
One Increasing Purpose

The Family Upstairs
The Family Upstairs
The Monster and the Girl
The Monster and the Girl
The Crime of Cain
The Crime of Cain
Two Stepchildren
Two Stepchildren
The Apple
The Apple

Loot
Loot

The Great Air Robbery
The Great Air Robbery

The Goddess
The Goddess